Study Name: Mechanisms of Vascular Dysfunction and Effect of Aerobic Interval Training on Cardiovascular Function in Type 2 Diabetes
Principal Investigator: Demetra Christou, Ph.D.
Phone: (352) 294 -1715
What is the Mechanisms of Vascular Dysfunction and Effect of Aerobic Interval Training on Cardiovascular Function in Type 2 Diabetes Study?
Individuals with type 2 diabetes are more likely to have poor blood vessel health which is a risk factor for developing heart disease. Exercise training may improve
blood vessel health, and lower the risk for heart disease. The purpose of this study is 1) to compare blood vessel function between adults with and without type 2 diabetes; and 2) to examine the effect of 2 different types of exercise training on blood vessel health in adults with type 2 diabetes.
Who Can Participate:
- Diagnosis for type 2 diabetes by ADA criteria
- Age 30 to 79 years old
- Sedentary or minimally physically active for at least the prior 1 year
Who Can’t Participate:
- History of diabetic proliferative retinopathy, autonomic or peripheral neuropathy
- History of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia)
- Hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic)
- History of renal impairment
- History of gout or hyperuricemia
- History of hepatic disease or infection with hepatitis B, C
- History of seizures, or other relevant on-going or recurrent illness
- Recent (within 3 months) or recurrent hospitalizations
- Use of tobacco products
- >5 % weight change in the prior 6 months.
- Current intake of medications that may affect study results
- Premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
- Pregnancy (positive urine pregnancy test) or lactation
What do I have to do as a participant?
You will be asked to visit the Integrative Cardiovascular Physiology Laboratory at the University of Florida. Cardiovascular function will be measured at baseline in adults with type 2 diabetes and in age-matched healthy controls. Research volunteers with type 2 diabetes who meet the inclusion criteria will be further randomized to the aerobic interval training group, continuous moderate exercise group or non-exercise control group. At the end of the 8-week randomized control exercise intervention, baseline measures will be repeated. Your total participation will be completed over about 3-4 months depending on scheduling availability. No additional compensation is offered.