| Study Name | Principal Investigator |
| Natural History Study “Pathway to Prevention” | |
| Hydroxychloroquine in Individuals At-risk for Type 1 Diabetes Mellitus (TN-22) | Desmond Schatz, M.D. |
| CTLA4-Ig (Abatacept)for Prevention of Abnormal Glucose Tolerance and Diabetes in Relatives At -Risk for Type 1 | Desmond Schatz, M.D. |