All Posts

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets (Journal of Proteome Research)

The transplantation of human pancreatic islets is a therapeutic possibility for a subset of type 1 diabetic patients who experience severe hypoglycemia. Pre- and post-transplantation loss in islet viability and function, however, is a major efficacy-limiting impediment. To investigate the effects of inflammation and hypoxia, the main obstacles hampering the…

Move over mice, canines may be next in line to study diabetes

STORY AT A GLANCE Dogs develop a form of diabetes that has similarities to type 1 diabetes in humans UF investigator and clinical assistant professor in veterinary medicine Allison O’Kell, DVM, is exploring the pathogenesis of canine diabetes to study possible similarities between how the diabetes develops in dogs and…

Mary Tyler Moore (1936-2017): Diabetes Educator and Advocate (Diabetes Care)

Dr. Atkinson and Dr. Nierras wrote a beautiful piece on how Mary Tyler Moore’s courage and strength in the face of her diabetes diagnosis has inspired and lent courage to many other individuals living with the disease, and the everlasting impact her tireless advocacy and work with congress has had…

Comparitive Pathogenesis of Autoimmune Diabetes in humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked? (Diabetes)

Despite decades of research in humans and mouse models of disease, substantial gaps remain in our understanding of pathogenic mechanisms underlying the development of type 1 diabetes. Furthermore, translation of therapies from preclinical efforts capable of delaying or halting β-cell destruction has been limited. Hence, a pressing need exists to identify…

Concentration-dependent Response to Pioglitazone in Nonalcoholic Steatohepatitis (Alimentary Pharmacology Therapeutics)

The authors aimed to evaluate the relationship between concentrations of pioglitazone and its active metabolites and treatment outcomes in patients with nonalcoholic steatohepatitis (NASH) .This study demonstrates the importance of pioglitazone exposure to variable response in patients with NASH, and indicates potential factors that may identify patients most likely to…

Local Delivery of Figolimod from 3-D Scaffolds Impacts Islet Graft Efficacy and Microenvironment in a Murine Diabetic Model (Journal of Tissue Engineering & Regenerative Medicine)

Overall, this study confirmed the ability to modulate local delivery of fingolimod in a sustained-release manner using a 3-D PDMS scaffold; however, the observed detrimental impacts at the site of islet transplantation do not support further investigation of local delivery at the graft site in murine models. Read more…