2021 marks the 100th year since Sir Frederick Banting, Charles Best, and Professor John Macleod from the University of Toronto reported the successful treatment of canine diabetes with a pancreas extract, now known as insulin. This discovery represented not only a remarkable scientific achievement, but more importantly, provided a life-saving…
This study evaluated the effects of dulaglutide vs placebo on liver and glycaemic/metabolic measurements in a population with Type 2 diabetes and in a subgroup with non-alcoholic fatty liver/non-alcoholic steatohepatitis.Once-weekly dulaglutide improved alanine aminotransferase, aspartate transaminase and gamma-glutamyl transpeptidase levels compared with placebo in a pattern consistent with…
Dendritic cell (DC) immunotherapy has been effective for prevention of type 1 diabetes (T1D) in NOD mice but fails to protect if initiated after active autoimmunity. As autoreactivity expands inter- and intramolecularly during disease progression, we investigated whether DCs unpulsed or pulsed with β cell antigenic dominant determinants (DD), subdominant determinants…
To examine the value of percent body fat (%BF) with body mass index (BMI) to assess the risk of abnormal blood glucose (ABG) among US adults who are normal weight or overweight. We hypothesised that normal-weight population with higher %BF is more likely to have ABG. Read More: http://bmjopen.bmj.com/content/8/4/e019200.long …
Data on cytokeratin-18 (K-18) and enhanced liver fibrosis (ELF) score in insulin-treated diabetes patients with non-alcoholic fatty liver disease (NAFLD) are limited. This study analyzed phase III data comparing basal insulin peglispro (BIL) and insulin glargine in type 1 (T1D), and type 2 diabetes (T2D) (insulin-naïve and insulin-treated). Alanine aminotransferase…
There has been a widespread misconception among physicians that African Americans are protected from developing nonalcoholic steatohepatitis (NASH). However, a formal histologic and metabolic comparison against well-matched Caucasians has never been performed. Read More: Â http://care.diabetesjournals.org/content/41/1/187.long Bril F, Portillo-Sanchez P, Liu IC, Kalavalapalli S, Dayton K,…
This study aimed to analyze adult kidney transplant recipients (KTRs) for the risk of new-onset diabetes after transplantation (NODAT) associated with viral serologies and immunosuppression regimens [tacrolimus (Tac) + mycophenolate (MPA), cyclosporine (CSA) + MPA, sirolimus (SRL) + MPA, SRL + CSA or SRL +Tac]. Read More: https://academic.oup.com/ndt/article/33/1/177/4554912 Santos AH JR, Chen C, Casey…
The transplantation of human pancreatic islets is a therapeutic possibility for a subset of type 1 diabetic patients who experience severe hypoglycemia. Pre- and post-transplantation loss in islet viability and function, however, is a major efficacy-limiting impediment. To investigate the effects of inflammation and hypoxia, the main obstacles hampering the…
The purpose of this study was to perform a prospective assessment of the long-term safety of statins in patients with prediabetes/T2DM and NASH. The authors concluded that statin therapy is safe in patients with prediabetes/T2DM and biopsy-proven NASH. Read More:Â Bril F, Sanchez P P, Lomonaco R,…
Dr. Atkinson and Dr. Nierras wrote a beautiful piece on how Mary Tyler Moore’s courage and strength in the face of her diabetes diagnosis has inspired and lent courage to many other individuals living with the disease, and the everlasting impact her tireless advocacy and work with congress has had…
