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Education And Research

Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes

UFDI investigators and collaborators found that granulocyte colony stimulating factor monotherapy did not affect C-peptide production, HbA1c, or insulin dose.This study supports the continued exploration of G-CSF and other mobilizing agents in subjects with T1D, but only when combined with immunodepleting agents where synergistic mechanisms of action have previously demonstrated…

Depressive symptoms in type 1 and type 2 diagnosed youth

UFDI Investigator Janet Silverstein, M.D. and collaborators examined the frequency of depressive symptoms among youth with T1D and T2D enrolled in Pediatric Diabetes Consortium registries. They identified depression symptoms in 13 percent of T1D and 22 percent of T2D participants. For youths with T1D, but not T2D, depressive symptoms correlated…

Type 1 Diabetes Genetics Consortium Publications

UFDI Investigator Patrick Concannon, Ph.D. UFDI Investigator Patrick Concannon, Ph.D. and University of Virginia School of Medicine Investigator Stephen S. Rich recently published two papers on their findings from the Type 1 Diabetes Genetics Consortium (T1DGC). Summary of the Type…