Dr. Campbell-Thompson and her collaborators recently published a paper titled ‘Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes.’
From the publication: “the study objective was to identify novel proteins that distinguish the pancreas from donors with T1D from the pancreas from patients with T2D, or autoantibody positive non-diabetic donors.”
Their publication identified proteins in pancreas tissue that are involved in inflammation, metabolic regulation and autoimmunity, all of which are pathways linked to and likely involved in type 1 and type 2 diabetes pathogenesis.
The publication states that “several new proteins were differentially upregulated in prediabetic, T1D, and T2D pancreas. The results identify proteins that could serve as novel prognostic, diagnostic, and therapeutic tools to preserve functional islet mass in Type 1 Diabetes.”