Mark Atkinson
Type 1 Diabetes Patients Retain Some Ability to Produce Insulin, UF Health Researchers Find
As an autoimmune disease, Type 1 diabetes has long been thought to result from a complete immune system killing of the insulin-producing beta cells within the pancreas. Now, University of Florida Health researchers have made a striking discovery: some of the pancreas’ ability to produce insulin may remain for decades…
Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics
UFDI Director Mark Atkinson, Ph.D. and collaborators found that GABA is rapidly absorbed and tolerated in human beings. They believe that its endocrine effects suggest potential therapeutic benefits for diabetes.
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes
UFDI and nPOD investigators found that the presence of β-cells as well as insulitis several years after T1D diagnosis in children and young adults suggest that the chronicity of islet autoimmunity extends well into the post-diagnosis period.
Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice
UFDI researchers Amanda Posgai, Ph.D. and Mark Atkinson, Ph.D. and collaborators examine a new approach for preserving beta cell function in patients with recent onset T1D.
Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics
UFDI Researcher Mark Atkinson, Ph.D. and collaborators found that that GABA is rapidly absorbed and tolerated in human beings, and its endocrine effects suggest potential therapeutic benefits for diabetes.
Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β
Individuals with schizophrenia and their first-degree relatives have higher rates of type 2 diabetes than the general population (18-30 vs. 1.2-6.3%), independent of body mass index and antipsychotic medication, suggesting shared genetic components may contribute to both diseases. The cause of this association remains unknown. Mutations in disrupted in schizophrenia…
Do you have extra diabetes supplies you no longer need?
UFDI Director Mark Atkinson, Ph.D. and Insulin for Life found a way to recycle unused diabetes supplies.
Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes
UFDI investigators and collaborators found that granulocyte colony stimulating factor monotherapy did not affect C-peptide production, HbA1c, or insulin dose.This study supports the continued exploration of G-CSF and other mobilizing agents in subjects with T1D, but only when combined with immunodepleting agents where synergistic mechanisms of action have previously demonstrated…
Immunoproteomic Profiling of Anti-Viral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays
UFDI investigators and collaborators at Arizona State University found that the Epstein-Barr virus may have a role in type 1 diabetes development.