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The WISE (Weightloss Intervention Surgical Effects) Brain Study

Study Name: Obesity and Type 2 Diabetes: Bariatric Surgery Effects on Brain Function Study

Principal Investigator: Ronald Cohen, Ph.D. | The University of Florida Department of Clinical Health and Psychology

Study Coordinator: Christa Ochoa, christamochoa@phhp.ufl.edu

Phone: 352-294-5837

What is the Obesity and Type 2 Diabetes: Bariatric Surgery Effects on Brain Function Study?

This study is being done to learn about the changes that weight loss causes on brain function, memory and thinking ability in adults. Potential bariatric surgery patients will have study specific information made available to them for their consideration at the bariatric or diabetes clinics at UFHealth & Shands Hospital, or at other community locations.

Who can participate?

  • Males and Females | Ages 20 – 75 years
  • Body Mass Index >35;
  • Diabetes or no diabetes;
  • Comfortable with MRI Scanning;
  • Willing to give a small blood sample on 3 occasions;
  • Capable of providing informed consent

What do I have to do as a participant?

There will be two groups of people studied. One group has chosen to have weight loss surgery to help them lose weight. Another group will not chose to have any weight loss surgery. All research participants will be tested on thinking and memory processes at the start of the study, after 12 weeks, and again at 18 months. They will have an MRI Brain Scan at those same times also to look at changes in the structure and function of the brain tissue.

Blood tests will be done to measure the sugar levels in the blood, and other proteins that may act as markers for disease.

Additional Information