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Metformin Therapy for Overweight Adolescents with Type 1 Diabetes

Study Name: Metformin Therapy for Overweight Adolescents with Type 1 Diabetes

Principal Investigator: Michael Haller, M.D. (352) 273-9264

Study Coordinators: Miriam Cintron (352) 273-5580

Jamie Thomas (352) 294-5758

Eleni Sheehan (352) 294-5764

Email: Michael Haller (hallemj@peds.ufl.edu) or Miriam Cintron (cintrm@peds.ufl.edu)

What is the Metformin Study?

We are conducting a study to see if a medication called metformin can improve blood sugar control when used in addition to insulin. Metformin is an oral medication that is used commonly to lower blood sugar in children and adults with type 2 diabetes. Metformin can help the body respond better to insulin. Although metformin has been well studied in type 2 diabetes, there are not a lot of studies that have evaluated it in type 1 diabetes

Who can participate?

  • Have been diagnosed with T1D more than 1 year ago.
  • Be at least 12 years old and not yet 20 years old.
  • Have a body mass index (BMI) greater than or equal to the 85th percentile
  • Be willing to comply with all study visits, procedures and tests.

What do I have to do as a participant?

There are six study visits which will occur over the course of approximately 6 months. Participants will be provided with the study medication (metformin or placebo) and related supplies, as well as a glucose meter and some test strips. If you decide to take part in this study, you will be randomly assigned (much like the flip of a coin) to receive either metformin or placebo. A placebo is used in research studies to show what effect a treatment has compared with taking nothing at all. You will be expected to come to the UF Clinical Research Center at the CTRB for all visits.

Additional Information:

Infomed Consent Form