JDRF Network for Pancreatic Organ Donors with Diabetes
Visit the JDRF nPOD website
The Network for Pancreatic Organ Donors with Diabetes (nPOD) program, supported by JDRF at the University of Florida, is the largest open research consortium dedicated to the study of the human pancreas.
Founded in 2007, the JDRF nPOD biorepository at the University of Florida supports the collection of pancreata and related tissues from organ donors with Type 1 diabetes which are made available to scientific investigators at international research sites in the U.S., England, Finland, Canada and Australia. Learn more »
With nearly $3 million in annual program funding, nPOD investigators are conducting more than 140 research studies that seek to unlock the mysteries of Type 1 diabetes. Researchers hope to address pressing questions related to how the disease develops and progresses including, but not limited to the immunopathology of T1D, beta cell physiology and dysfunction, pancreas development, beta cell regeneration, environmental factors and medical imaging.
Thanks to nPOD, I think we’re at the precipice of being able to change much of what’s been put into textbooks and review articles on Type 1 diabetes in terms of how the disease develops and what are its potential causes.”
— Mark Atkinson, Ph.D., Eminent Scholar for Diabetes Research at the University of Florida and nPOD Executive Director
The Network for Pancreatic Organ Donors with Diabetes (nPOD) has three main goals:
- Obtain specimens from organ donors with T1D and establish a research resource of pancreas and disease relevant tissues (pancreatic lymph nodes, spleen, thymus, blood, and other) from organ donors with T1D, obtained at any point after clinical diagnosis, or during the prediabetes phase, when islet autoimmunity silently leads to beta cell destruction (donors identified by screening for islet autoantibodies);
- Distribute specimens to JDRF-nPOD scientists, anywhere in the world, for comprehensive and diversified investigations of human T1D;
- Promote collaboration, by using tissue- and real-time data-sharing, and by developing and managing synergistic project interactions as well as focused working groups, all to facilitate a comprehensive understanding of human T1D and identify new therapeutic targets.
nPOD Research Update
In a recent study, University of Florida T1D investigator Martha Campbell-Thompson, D.V.M., Ph.D. and nPOD colleagues published findings that organ donors who lived with Type 1 diabetes had smaller pancreas weights than their counterparts – up to 46 percent smaller. This important discovery is key to understanding the trajectory of the disease and may one day help lead to interventions to prevent it. More »
JDRF–nPOD investigators are continually humbled by the decision families make to contribute to Type 1 diabetes research through the gift of organ donation. While we make every effort to honor the wishes of the donor family, we cannot accept all donations. At this time, the following groups of donor gifts are of particular importance:
- Donors with longstanding Type 1 diabetes;
- Donors with recently diagnosed Type 1 diabetes (less than seven years duration);
- Donors who are positive for Type 1 diabetes autoantibodies, are between the ages of 0-45, and are not diagnosed with Type 1 diabetes.
Phone: (352) 273-8277 | Toll Free: 866-731-6585
nPOD Staff at the University of Florida
Current nPOD Investigators at the University of Florida
|Mark Atkinson, Ph.D. – JDRF nPOD Executive Director
Projects: Quantitative and qualitative evaluation of the endocrine & exocrine pancreas in type 1 diabetes; Beta cell regeneration for Type 1 diabetes; De-differentiation during progression of beta cell loss in type 1 diabetes; Pancreatic Immunologic and Metabolic Parameters; Diabetes and Pancreatic Cancers: Pilot study with molecular profiling; Human pancreatic tissue proteome of type 1 diabetes; Pancreatic duct glands in type 1 diabetes
|Todd Brusko, Ph.D.
Project: Molecular Signature of Autoimmune T cells in Type 1 Diabetes and Treg TCR deep sequencing. Detect Cd226+ Treg and Teff ininsulitis patient samples
|Martha Campbell-Thompson, D.V.M., Ph.D. – Director of the Organ Procurement and Pathology Core
Projects: Beta cell regeneration for Type 1 Diabetes; Diabetes and Pancreatic Cancers: Pilot study with molecular profiling; Mapping the histopathological landscape of human T1D: a pilot study (CLARITY)
|Mitchell Knutson, Ph.D.
Project: Molecular mechanisms of iron uptake by pancreatic beta cells and their contribution to the development of diabetes
|Joe Larkin, Ph.D.
Project: Dynamic Survey of T Cell Repertoire Targeting Pancreatic Beta Cells
|Clayton Mathews, Ph.D.
Project: Islet resistance to T1D
|Clive Wasserfall, M.S.
Projects: Beta cell regeneration for Type 1 Diabetes; Humoral Immunity in Type 1 Diabetes; UF Autoantibody Core
|Shannon Wallet, Ph.D.
Projects: Characterization of Mesencymal Stem Cells in T1D; Role of mucosal epithelium in autoreactivity
For research, press and media inquiries, contact:
University of Florida, College of Medicine
1329 SW 16th Street, Room 4230
PO Box 100275
Gainesville, FL 32608-1128
Phone: (352) 273-8277 | Toll Free: 866-731-6585