Clive Wasserfall, MS
Our laboratory focus is on the immunopathogenesis of type 1 diabetes. Aspects of this work include refining prediction of disease onset/progression through the use of genetic markers and autoantibody assessment. The mechanism of disease is explored on the cellular and molecular level in order to better understand the pathogenesis of this disease and thereby lead to the goal of our program which is to prevent type 1 diabetes in those at risk. The induction of immune tolerance to the insulin secreting endocrine pancreas is the current strategy being pursued for both primary intervention of disease and to improve islet transplantation without the need for immunosuppression in those individuals that already have type 1 diabetes.