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Published Studies

Comparitive Pathogenesis of Autoimmune Diabetes in humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked? (Diabetes)

Despite decades of research in humans and mouse models of disease, substantial gaps remain in our understanding of pathogenic mechanisms underlying the development of type 1 diabetes. Furthermore, translation of therapies from preclinical efforts capable of delaying or halting β-cell destruction has been limited. Hence, a pressing need exists to identify…

Concentration-dependent Response to Pioglitazone in Nonalcoholic Steatohepatitis (Alimentary Pharmacology Therapeutics)

The authors aimed to evaluate the relationship between concentrations of pioglitazone and its active metabolites and treatment outcomes in patients with nonalcoholic steatohepatitis (NASH) .This study demonstrates the importance of pioglitazone exposure to variable response in patients with NASH, and indicates potential factors that may identify patients most likely to…

Local Delivery of Figolimod from 3-D Scaffolds Impacts Islet Graft Efficacy and Microenvironment in a Murine Diabetic Model (Journal of Tissue Engineering & Regenerative Medicine)

Overall, this study confirmed the ability to modulate local delivery of fingolimod in a sustained-release manner using a 3-D PDMS scaffold; however, the observed detrimental impacts at the site of islet transplantation do not support further investigation of local delivery at the graft site in murine models. Read more…

Path Analysis of campus walkability/bikeability and college students’ physical activity attitudes, behaviors and body mass index (Am J Health Promot).

This study assessed the relationship between the walkability/bikeability of college campuses and students’ body mass index (BMI) View article here.  Horacek et al. (2016). Path Analysis of campus walkability/bikeability and college students’ physical activity attitudes, behaviors and body mass index. Am J Health Promot, DOI: 10.1177/0890117116666357…