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New funding opportunities available

From the National Institutes of Health’s National Institute of Aging: Diabetes and Cardiovascular Disease in Older Adults (R01) “This Funding Opportunity Announcement invites applications that propose basic, clinical, and epidemiological outcomes research on the impact of age on the development of, diagnosis, and management of diabetes…

Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β

Individuals with schizophrenia and their first-degree relatives have higher rates of type 2 diabetes than the general population (18-30 vs. 1.2-6.3%), independent of body mass index and antipsychotic medication, suggesting shared genetic components may contribute to both diseases. The cause of this association remains unknown. Mutations in disrupted in schizophrenia…

JDRF requests letters of intent

JDRF recently posted two new opportunities. The first is titled Overcoming Obstacles to Achieving Immune Tolerance in Type 1 Diabetes. From JDRF: “JDRF is soliciting letters of intent for the identification of key barriers in the way of therapeutically restoring immune tolerance in type 1 diabetes…

Funding opportunity available

From the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases: Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01) “The goal of this opportunity is to support innovative research in humans to elucidate the role of HIV infection, including relevant host conditions…

Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice

In Type 1 diabetic (T1D) human monocytes, STAT5 aberrantly binds to epigenetic regulatory sites of two proinflammatory genes, CSF2 (encoding granulocyte–macrophage colony-stimulating factor) and PTGS2 (encoding prostaglandin synthase 2/cyclooxygenase 2). Bicongenic B6.NOD C11bxC1tb mice re-create this phenotype of T1D monocytes with only two nonobese diabetic (NOD) Idd subloci (130.8 Mb–149.7…

Human norovirus culture in B cells

UF Researchers Shannon Wallet, Ph.D. and Christina Graves, along with collaborators, studied human noroviruses, which are a leading cause of foodborne disease and severe childhood diarrhea, as well as a cause of gastroenteritis outbreaks worldwide.

JDRF Requests Letters of Intent for Discovery and Development of Immune Tolerance Delivery Systems for Antigen Specific Therapies in Type 1 Diabetes

From JDRF: Purpose: JDRF is soliciting letters of intent (LOI) for the discovery, development and pre-clinical testing of tolerogenic delivery systems (TDS) of diabetes-specific autoantigens designed to prevent and/or reverse type 1 diabetes (T1D). JDRF is committed to translation of research findings towards clinical results and is most…