Comparitive Pathogenesis of Autoimmune Diabetes in humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked? (Diabetes)

Published: May 25th, 2017

Category: published studies

Despite decades of research in humans and mouse models of disease, substantial gaps remain in our understanding of pathogenic mechanisms underlying the development of type 1 diabetes. Furthermore, translation of therapies from preclinical efforts capable of delaying or halting β-cell destruction has been limited. Hence, a pressing need exists to identify alternative animal models that reflect human disease.

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O’Kell AL, Wasserfall C, Catchpole B et al. (2017). Comparitive Pathogenesis of Autoimmune Diabetes in humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked? Diabetes, 66(6) 1443-1452.