Local Delivery of Figolimod from 3-D Scaffolds Impacts Islet Graft Efficacy and Microenvironment in a Murine Diabetic Model (Journal of Tissue Engineering & Regenerative Medicine)

Published: May 24th, 2017

Category: published studies

Overall, this study confirmed the ability to modulate local delivery of fingolimod in a sustained-release manner using a 3-D PDMS scaffold; however, the observed detrimental impacts at the site of islet transplantation do not support further investigation of local delivery at the graft site in murine models.

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Frei AW, Li Y, Buchwald P & Stabler CL. (2017). Local Delivery of Figolimod from 3-D Scaffolds Impacts Islet Graft Efficacy and Microenvironment in a Murine Diabetic Model. J Tissue Eng Regen Med doi: 10.1002/term.2464