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UF Researchers Present at ADA’s 74th Scientific Sessions

Published: June 21st, 2014

Category: News

lge_rruvf74_Meeting-ImageFrom population health to mitochondrial metabolism, UF and UF Health faculty, postdoctoral fellows, and graduate students took part in the American Diabetes Association’s 74th Scientific Sessions held June 13-17, 2014 at the Moscone Center in San Francisco, California. The following is a comprehensive list of their original abstract posters, oral presentations, and audio posters during the conference. This year’s volume of submissions represent one of the largest showcases of research emanating from UF. We congratulate these individuals and look forward to their future achievements.

 

Haller smallTitle of Abstract: Combination Low-Dose Antithymocyte Globulin (ATG) and Granulocyte Colony Stimulating Factor (GCSF) Preserves Beta-Cell Function in Patients with Established Type 1 Diabetes

Name: Michael J. Haller, Mark A. Atkinson, Stephen E. Gitelman, Peter A. Gottlieb, Aaron Michels, Srinath Sanda, Stephen Rosenthal, Mary Alice Dennis, Miriam Cintron, Rebecca Wesch, Marcia Wertz, Kieran Mcgrail, Jenna Lungaro, Mara Schwartz, Maigan A. Hulme, Jenna Lungaro, Todd M. Brusko, Clayton E. Mathews, Clive Wasserfall, Desmond A. Schatz, Gainesville, FL, San Francisco, CA, Aurora, CO, Denver, CO

Details:  17 adult Type 1 diabetes patients were treated for two weeks with the cocktail therapy and then followed for a year. Another eight patients were given a placebo. By the end of the year,  patients treated with the cocktail had increased their ability to produce insulin. This indicates that the Thymoglobulin was successful in killing bad immune system cells, and the Neulasta was successful in stimulating new, healthy immune cells.

 


 

103009_VitaminDSupTitle of Abstract: Youth with Type 2 Diabetes (T2D) Have More Vitamin D Deficiency than Youth with Type 1 Diabetes (T1D): The Pediatric Diabetes Consortium (PDC) (full abstract here)

Name: Jamie Wood, Fida Bacha, Steven M. Willi, Eda Cengiz, William V. Tamborlane, Brigid Gregg, Georgeanna J. Klingensmith, Desmond A. Schatz, Katrina Ruedy, Roy W. Beck, Craig Kollman, Crystal Connor, Heidi Haro, Los Angeles, CA, Houston, TX, Philadelphia, PA, New Haven, CT, Ann Arbor, MI, Aurora, CO, Gainesville, FL, Tampa, FL

Details: Vitamin D supports healthy bone development as well as potential benefits on glycemic control in management of diabetes. 5-hydroxy vitamin D (25OHD) levels were measured among 495 youth ages 10-21 diagnosed with type 1 and type 2 diabetes.  Vitamin D deficiency occurred in 48% of T2D youth vs 17% of T1D youth. Variation by geographic region (e.g. higher latitudes), exposure to sun, and race/ethnicity all likely reflect the variation.

 


 

Title of Abstract: Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) and Disease Severity among African Americans (AA) with Prediabetes (preDM) or Type 2 Diabetes (T2DM) (full abstract here)

Name:
 Fernando Bril, Sreevidya Subbarayan, Maryann Maximos, Paola Portillo Sanchez, Romina Lomonaco, Diane Biernacki, Amitabh Suman, Michelle Weber, Kenneth Cusi, Gainesville, FL

Details:
 Researchers examined whether today’s monitoring methods underrepresent risk of of non-alcoholic fatty liver disease (NAFLD) and severe liver disease in African Americans living with pre-diabetes and type 2 diabetes (T2DM), as compared to Whites and Hispanics. 93 patients with preDM/T2DM were screened for NAFLD. 80% of African Americans screened had confirmed cases of NAFLD, demonstrating that African Americans are truly at risk of NAFLD/NASH and early screening is as important as for other ethnicities to prevent progressive liver disease.

 


 

Title of Abstract: IL-12 and IL-18 Potentiate Th1-immunity and Cytotoxic T Cell-mediated Killing of Human ßLox5 Cells (full abstract here)
Name: Christopher A. Fuhrman, Brittney N. Newby, Priya Saikumar Lakshmi, Howard R. Seay, Mark A. Atkinson, Desmond A. Schatz, Michael J. Haller, Clayton E. Mathews, Todd M. Brusko, Gainesville, FL

Title of Abstract: Granulocyte Colony Stimulating Factor (GCSF) Fails to Preserve Beta-Cell Function in Patients with Recent Onset Type 1 Diabetes (T1D) (full abstract here)
Name: Michael J. Haller, Miriam Cintron, Kieran Mcgrail, Todd M. Brusko, Clive Wasserfall, Maigan Hulme, Clayton E. Mathews, Mark A. Atkinson, Desmond A. Schatz, Gainesville, FL

Title of Abstract: Novel Systematic Virus Antibody Survey in New-Onset Type 1 Diabetes by Protein Arrays (full abstract here)
Name: Xiaofang Bian, Garrick Wallstrom, Andrea Throop, Jin Park, Jason Steel, Clive Wasserfall, Mark A. Atkinson, Desmond A. Schatz, Ji Qiu, Joshua Labaer, Tempe, AZ, Gainesville, FL

Title of Abstract: Frequency of Self-Monitoring of Blood Glucose (SMBG) and A1C Levels in Youth with Type 2 Diabetes (T2D): Data from the Pediatric Diabetes Consortium (PDC) T2D Registry Consortium (PDC) T2D Registry (full abstract here)
Name: Michael J. Haller, Eda Cengiz, William V. Tamborlane, Sani Roy, Apisadaporn Thambundit, Roy W. Beck, Craig Kollman, Katrina Ruedy, Crystal Connor, Bruce Buckingham, Brigid Gregg, Inas Thomas, Gainesville, Fl, New Haven, Ct, Philadelphia, Pa, Tampa, Fl, Stanford, Ca, Ann Arbor, MI

Title of Abstract: Granulocyte Colony Stimulating Factor (GCSF) Fails to Preserve Beta-Cell Function in Patients with Recent Onset Type 1 Diabetes (T1D) (full abstract here)
Name: Michael J. Haller, Miriam Cintron, Kieran Mcgrail, Todd M. Brusko, Clive Wasserfall, Maigan Hulme, Clayton E. Mathews, Mark A. Atkinson, Desmond A. Schatz, Gainesville, FL

Title of Abstract: Haplotypes/Genotypes Influence Progression to Type 1 Diabetes (T1D) in Autoantibody-Positive Relatives
Name: Alberto Pugliese, David Boulware, Craig A. Beam, Sunanda Babu, Jennifer B. Marks, Desmond A. Schatz, Linda A. Dimeglio, Carmella Evans-molina, Leonard C. Harrison, Carla J. Greenbaum, Dorothy J. Becker, Andrea K. Steck, Henry Rodriguez, The Type 1 Diabetes Trialnet Study Group, Miami, FL, Tampa, FL, Denver, CO, Gainesville, FL, Indianapolis, IN, Parkville, Australia, Seattle, WA, Pittsburgh, PA, Aurora, CO

Title of Abstract: CD226 and TIGIT Identify Human Regulatory T Cells with Unique Functional Activities
Name: Christopher A. Fuhrman, Wen-i Yeh, Howard Seay, Priya Saikumar Lakshmi, Mark A. Atkinson, Desmond A. Schatz, Jeffrey A. Bluestone, Todd M. Brusko, Gainesville, FL, San Francisco, CA

Title of Abstract: Mitochondrial Dysfunction Contributes to Altered T Cell Responses in Type 1 Diabetes Patients (full abstract here)
Name: Jing Chen, Daniel J. Perry, Matthew R. Kimbrell, Todd M. Brusko, Clayton E. Mathews, Gainesville, FL

Title of Abstract: Branched-Chain Amino Acids Alter Mitochondrial Fat Metabolism in Mice with Nonalcoholic Fatty Liver Disease (full abstract here)
Name: Nishanth E. Sunny, Adriane K. Hines, Srilaxmi Kalavalapalli, Timothy J. Garrett, Justin T. Mathew, Kenneth Cusi, Gainesville, FL

Title of Abstract: Classification of Depression Symptoms in Youth with Type 1 and Type 2 Diabetes in the Pediatric Diabetes Consortium (PDC) (full abstract here)
Name: Janet Silverstein, Eda Cengiz, William V. Tamborlane, Steven M. Willi, Georgeanna J. Klingensmith, Satya Shanmugham, Jamie Wood, Fida Bacha, Joyce M. Lee, Maria J. Redondo, Roy W. Beck, Craig Kollman, Crystal Connor, Katrina Ruedy, Gainesville, FL, New Haven, CT, Philadelphia, PA, Aurora, CO, Stanford, CA, Los Angeles, CA, Houston, TX, Ann Arbor, MI, Tampa, FL

Title of Abstract: Does Nonalcoholic Fatty Liver Disease (NAFLD) Develop in Insulin-Sensitive Patients? (full abstract here)
Name: Fernando Bril, Romina Lomonaco, Paola Portillo Sanchez, Beverly Orsak, Maryann Maximos, Joan Finch, Amy Webb, Kenneth Cusi, Gainesville, FL, San Antonio, TX

Title of Abstract: Effects of Extended Pioglitazone Treatment (PIO) on Bone Metabolism in Patients with Prediabetes and Type 2 Diabetes Mellitus (T2DM) (full abstract here)
Name:
Paola Portillo Sanchez, Fernando Bril, Romina Lomonaco, Maryann Maximos, Jan Bruder, Beverly Orsak, Joan Hecht, Kenneth Cusi, Gainesville, FL, San Antonio, TX

Title of Abstract: High Risk of Nonalcoholic Fatty Liver Disease (NAFLD) and Steatohepatitis (NASH) in Obese Patients with Type 2 Diabetes Mellitus (T2DM) and Normal Liver Aminotransferases (full abstract here)
Name: Maryann Maximos, Fernando Bril, Paola Portillo Sanchez, Romina Lomonaco, Diane Biernacki, Sreevidya Subbarayan, Amitabh Suman, Kenneth Cusi, Gainesville, FL

Title of Abstract: IFNγ Inhibits Type 1 Diabetes by Blunting Autoreactive CD8 T Cell Responses (full abstract here)
Name: John P. Driver, Deanna J. Lamont, Caroline Mcphee, Harry Chapman, Dave V. Serreze, Gainesville, FL, Bar Harbor, ME

Title of Abstract: Kinship vs. Professional Resources: Disparities in Social Support Systems for Families Living with Type 1 Diabetes ( full abstract here)
Name: Ashby F. Walker, Desmond A. Schatz, Cathryn Johnson, Janet Silverstein, Shannon Lyles, Henry Rohrs, Mars Hill, NC, Gainesville, FL, Atlanta, GA